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KMID : 0525720160210040229
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Journal of Chitin and Chitosan
2016 Volume.21 No. 4 p.229 ~ p.235
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Role of Chitosan Nanoparticles in Drug Delivery - A Review
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Lowe Baboucarr
Chang Kwan-Young
Hwang Jae-Ho
Venkatesan Jayachandran
Kim Dong-Gyun
Kim Se-Kwon
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Abstract
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There have been extensive studies on naturally occurring polymers such as chitosan. Chitosan have been studied as primary carrier of several therapeutic drugs and other biomolecules. The use of chitosan in this area of biomedical research is favored by its biocompatible, biodegradable, hemostatic maintenance, anti-microbial, anticancerogenic, and anticholesteremic properties. The use of chitosan nanoparticles have favored encapsulation of therapeutic anti-tumor drugs producing control and sustained release profiles. In this review we examined the roles chitosan nanoparticles in controlled and sustain release mechanisms and how they are co-conjugated with other materials for enhanced target delivery of drug in cancer cells.
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KEYWORD
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Chitosan, Drug delivery, Cancer and Nanoparticles
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